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    Why choose NICE®?

    NICE® improved the accuracy of results and test success rate by using a multi-Z score through the sizeselection method, developed through research and development by EDGC. By selectively enriching short cfDNA fragments, the fetal DNA fraction was increased by relatively enriching fetal-derived cfDNA. In addition, by selectively enriching long cfDNA fragments and enriching maternal-derived cfDNA, factors causing abnormal chromosomal abnormalities in the mother were eliminated. Therefore, this method reduced false- positive results by more than half, had higher sensitivity, specificity, and accuracy over than other NIPTs, and could improve overall performance.

Table2. NICE® vs Other NIPT services

  • Sensitivity
    (False-positive rates)
  • EDGC
    NICE®
  • Sequenom
    MaterniT21™
  • Illumina
    Verifi®
  • Ariosa
    Harmony™
  • Natera
    Panorama™
  • Trisomy 21
    Down syndrome
  • >99%
    (<0.01%)
  • 99.1%
    (0.2%)
  • >99.9%
    (0.3%)
  • >99%
    (<0.1%)
  • 99%
    (0%)
  • Trisomy 18
    Edwards syndrome
  • >96.5%
    (<0.01%)
  • 96.9%
    (0.01%)
  • 97.3%
    (0.4%)
  • 96.7%
    (<0.1%)
  • 94.1%
    (<0.1%)
  • Trisomy13
    Patau syndrome
  • >92.31%
    (<0.01%)
  • 89.3%
    (0.3%)
  • 87.5%
    (0.1%)
  • 80%
    (0.05%)
  • >99%
    (0%)
  • Monosomy X
    Turner syndrome
  • >99.99%
    (<0.01%)
  • 94.7%
    (0.5%)
  • 95%
    (1.0%)
  • 96.7%
    (unreported)
  • 94.7%
    (<0.1%)
  • Sex chromosome
    Trisomies
  • >99.99%
    (0%)
  • >99.9%
  • 67-100%
  • 67-100%
  • 73.1%
  • Female
  • >99%
    (0%)
  • 97.9%
    (0.5%)
  • 97.6%
    (0.8%)
  • >99%
    (unreported)
  • >99.9%
    (0%)
  • Male
  • >99%
    (0%)
  • 99.4%
    (2.1%)
  • 99.1%
    (1.1%)
  • >99%
    (0.01%)
  • >99.9%
    (0%)
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